Biodistribution of a Mitochondrial Metabolic Tracer, [¹⁸F]F-AraG, in Healthy Volunteers.

ABSTRACT:

Purpose

[¹⁸F]F-AraG is a radiolabeled nucleoside analog that shows relative specificity for activated T cells. The aim of this study was to investigate the biodistribution of [¹⁸F]F-AraG in healthy volunteers and assess the preliminary safety and radiation dosimetry.

Methods

Six healthy subjects (three female and three male) between the ages of 24 and 60 participated in the study. Each subject received a bolus venous injection of [¹⁸F]F-AraG (dose range: 244.2-329.3 MBq) prior to four consecutive PET/MR whole-body scans. Blood samples were collected at regular intervals and vital signs monitored before and after tracer administration. Regions of interest were delineated for multiple organs, and the area under the time-activity curves was calc

SUBMITTER: Levi J 

PROVIDER: S-EPMC9400547 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature