Green synthesis of coumarin derivatives using Bronsted acidic pyridinium based ionic liquid [MBSPy][HSO₄] to control an opportunistic human and a devastating plant pathogenic fungus Macrophomina phaseolina.

ABSTRACT: An eco-friendly simple protocol has been devised for the preparation of coumarin derivatives using doubly Brønsted acidic task specific ionic liquid (TSIL) as a catalyst. Solvent-free conditions were employed for the reaction of different substituted phenols with β-ketoester in TSIL to produce corresponding substituted coumarin derivatives in good to excellent yields at ambient conditions; at room temperature and with reduced reaction times. The ionic liquid catalyst can be recycled and reused up to five times. All the synthesized coumarins were evaluated for their antifungal activities against Macrophomina phaseolina, a plant as well as an opportunistic human pathogenic fungus affecting more than 500 plant species worldwide and with no registered commercial fungicide available agai

SUBMITTER: Uroos M 

PROVIDER: S-EPMC9400593 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature