Targeting cytoskeletal phosphorylation in cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Llorente-Gonzalez C
PROVIDER: S-EPMC9400739 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Targeting cytoskeletal phosphorylation in cancer.
Llorente-González Clara C González-Rodríguez Marta M Vicente-Manzanares Miguel M
Exploration of targeted anti-tumor therapy 20210628 3
Phosphorylation of cytoskeletal proteins regulates the dynamics of polymerization, stability, and disassembly of the different types of cytoskeletal polymers. These control the ability of cells to migrate and divide. Mutations and alterations of the expression levels of multiple protein kinases are hallmarks of most forms of cancer. Thus, altered phosphorylation of cytoskeletal proteins is observed in most cancer cells. These alterations potentially control the ability of cancer cells to divide, ...[more]
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