Understanding doxorubicin associated calcium remodeling during triple-negative breast cancer treatment: an in silico study.

ABSTRACT:

Aim

Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer with high heterogeneity, rapid progression, and paucity of treatment options. The most effective chemotherapeutic drug used to treat TNBC is doxorubicin (Doxo) which is an anthracycline antibiotic. However, Doxo treatment alters cytosolic calcium dynamics leading to drug-resistance condition. The aim of this study is to capture the alterations in the activity of various calcium channels and pumps during Doxo treatment and their consequences on cytosolic calcium dynamics that ultimately result in drug resistance.

Methods

In the present study, a mathematical model is proposed to capture the complex dynamical landscape of intracellular calcium during Doxo treatment. This study provides an in

SUBMITTER: Arora G 

PROVIDER: S-EPMC9400755 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature