Potential benefit of β-glucans as adjuvant therapy in immuno-oncology: a review.

ABSTRACT: Fungal compounds have long been used for centuries as food supplements. β-glucans have been identified as the most interesting molecules with beneficial effects in several chronic diseases. In vitro studies have shown that they are able to elicit the immune cells maturation and activation with the result of an increased release of proinflammatory cytokines and chemokines and a stimulation of anti-bacterial activity of macrophages and neutrophils. As β-glucans enhance pathogen elimination through non-self antigens identification, they can also direct immune response against tumor cells. These compounds also stimulate the activity on adaptive immune cells and they have been regarded as biological response modifiers. In this way, β-glucans can be exploited as adjuvant cancer therapy, i

SUBMITTER: Cognigni V 

PROVIDER: S-EPMC9400766 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature