Pharmacophore-guided Virtual Screening to Identify New β₃ -adrenergic Receptor Agonists.

ABSTRACT: The β₃ -adrenergic receptor (β₃ -AR) is found in several tissues such as adipose tissue and urinary bladder. It is a therapeutic target because it plays a role in thermogenesis, lipolysis, and bladder relaxation. Two β₃ -AR agonists are used clinically: mirabegron 1 and vibegron 2, which are indicated for overactive bladder syndrome. However, these drugs show adverse effects, including increased blood pressure in mirabegron patients. Hence, new β₃ -AR agonists are needed as starting points for drug development. Previous pharmacophore modeling studies of the β₃ -AR did not involve experimental in vitro validation. Therefore, this study aimed to conduct prospective virtual screening and confirm the biological activity of virtual hits. Li

SUBMITTER: Ujiantari NSO 

PROVIDER: S-EPMC9400856 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature