Supramolecular Rotaxane-Based Multi-Modal Probes for Cancer Biomarker Imaging.
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ABSTRACT:
SUBMITTER: d'Orchymont F
PROVIDER: S-EPMC9400884 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Publications
Supramolecular Rotaxane-Based Multi-Modal Probes for Cancer Biomarker Imaging.
d'Orchymont Faustine F Holland Jason P JP
Angewandte Chemie (International ed. in English) 20220520 29
Mechanically interlocked molecules present opportunities to construct therapeutic drugs and diagnostic imaging agents but harnessing supramolecular chemistry to make biologically active probes in water is a challenge. Here, we describe a rotaxane-based approach to synthesise radiolabelled proteins and peptides for molecular imaging of cancer biomarkers in vivo. Host-guest chemistry using β-cyclodextrin- and cucurbit[6]uril-catalysed cooperative capture synthesis produced gallium-68 or zirconium- ...[more]
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