Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis.

ABSTRACT: Multidrug-resistant tuberculosis (MDR-TB) accounts for one third of the annual deaths due to antimicrobial resistance¹. Drug resistance-conferring mutations frequently cause fitness costs in bacteria^2-5. Experimental work indicates that these drug resistance-related fitness costs might be mitigated by compensatory mutations^6-10. However, the clinical relevance of compensatory evolution remains poorly understood. Here we show that, in the country of Georgia, during a 6-year nationwide study, 63% of MDR-TB was due to patient-to-patient transmission. Compensatory mutations and patient incarceration were independently associated with transmission. Furthermore, compensatory mutations were overrepresented among isolates from incarcerated individuals that also fre

SUBMITTER: Gygli SM 

PROVIDER: S-EPMC9400913 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature