Investigating the Role of Sulfate Groups for the Binding of Gd³⁺ Ions to Glycosaminoglycans with NMR Relaxometry.

ABSTRACT: Glycosaminoglycans (GAGs) are highly negatively charged macromolecules with a large cation binding capacity, but their interaction potential with exogeneous Gd³⁺ ions is under-investigated. These might be released from chelates used as Gadolinium-based contrast agents (GBCAs) for clinical MR imaging due to transmetallation with endogenous cations like Zn²⁺ . Recent studies have quantified how an endogenous GAG sequesters released Gd³⁺ ions and impacts the thermodynamic and kinetic stability of some GBCAs. In this study, we investigate and compare the chelation ability of two important GAGs (heparin and chondroitin sulfate), as well as the homopolysaccharides dextran and dextran sulfate that are used as models for alternative macromolecular chelators. Our co

SUBMITTER: Werner P 

PROVIDER: S-EPMC9400987 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature