Distinct translatome changes in specific neural populations precede electroencephalographic changes in prion-infected mice.

ABSTRACT: Selective vulnerability is an enigmatic feature of neurodegenerative diseases (NDs), whereby a widely expressed protein causes lesions in specific cell types and brain regions. Using the RiboTag method in mice, translational responses of five neural subtypes to acquired prion disease (PrD) were measured. Pre-onset and disease onset timepoints were chosen based on longitudinal electroencephalography (EEG) that revealed a gradual increase in theta power between 10- and 18-weeks after prion injection, resembling a clinical feature of human PrD. At disease onset, marked by significantly increased theta power and histopathological lesions, mice had pronounced translatome changes in all five cell types despite appearing normal. Remarkably, at a pre-onset stage, prior to EEG and neuropathological

SUBMITTER: Kaczmarczyk L 

PROVIDER: S-EPMC9401167 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature