Association between proteinuria trajectories and outcomes in critically ill patients with sepsis or shock.

ABSTRACT:

Background

Proteinuria results from kidney damage and can be a predictor of illness severity and mortality in the intensive care unit (ICU). However, the optimal timing of proteinuria measurements and the reference values remain undetermined. Our objective was to identify the patterns of proteinuria change associated with mortality in ICU patients with sepsis or shock.

Methods

This monocentric retrospective cohort study performed from April 2010 to April 2018 involved all ICU patients with sepsis or shock and at least two measurements of proteinuria from a 24h-urine collection during the first 10 days of ICU stay, the first of which was made within 48h after ICU admission. We identified proteinuria trajectories by a semi-parametric mixture model and analysed the association

SUBMITTER: Monge R 

PROVIDER: S-EPMC9401181 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature