STING-pathway modulation to enhance the immunogenicity of adenoviral-vectored vaccines.

ABSTRACT: Traditional chemical adjuvants remain a practical means of enhancing the immunogenicity of vaccines. Nevertheless, it is recognized that increasing the immunogenicity of viral vectors is challenging. Recently, STING ligands have been shown to enhance the efficacy of different vaccine platforms, but their affectivity on viral-vectored vaccination has not been fully assessed. In this study we used a multi-pronged approach to shed light on the immunological properties and potential mechanisms of action of this type of adjuvant and focused our study on replication-deficient human adenovirus serotype 5 (AdHu5). When the STING ligand 2'3'-cGAMP was mixed with AdHu5, the adjuvant enhanced anti-vector immune responses while decreasing the transgene-specific CD8⁺ T cell response. Studies

SUBMITTER: Padron-Regalado E 

PROVIDER: S-EPMC9401198 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature