Reduced diversity of intestinal T-cell receptor repertoire in patients with Crohn's disease.

ABSTRACT:

Background

The intestinal microenvironment directly determines the human T-cell receptor (TCR) repertoire. Despite its extreme diversity, TCR repertoire analysis may provide a better understanding of the immune system in patients with inflammatory bowel disease.

Methods

To investigate TCR repertoires in the intestinal mucosa, RNA sequencing was performed for inflamed and non-inflamed intestinal mucosa samples obtained from 13 patients with Crohn's disease (CD) and healthy mucosa from nine non-IBD controls.

Results

The gene expression frequency of the TCR repertoire showed a clear separation between inflamed mucosa of patients with CD and healthy mucosa of non-IBD controls in the hierarchical clustering heatmap. The richness of TCR repertoires measured by the Chao1 ind

SUBMITTER: Hong SN 

PROVIDER: S-EPMC9401206 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature