High-specificity protection against radiation-induced bone loss by a pulsed electromagnetic field.

ABSTRACT: Radiotherapy increases tumor cure and survival rates; however, radiotherapy-induced bone damage remains a common issue for which effective countermeasures are lacking, especially considering tumor recurrence risks. We report a high-specificity protection technique based on noninvasive electromagnetic field (EMF). A unique pulsed-burst EMF (PEMF) at 15 Hz and 2 mT induces notable Ca²⁺ oscillations with robust Ca²⁺ spikes in osteoblasts in contrast to other waveforms. This waveform parameter substantially inhibits radiotherapy-induced bone loss by specifically modulating osteoblasts without affecting other bone cell types or tumor cells. Mechanistically, primary cilia are identified as major PEMF sensors in osteoblasts, and the differentiated ciliary expression dominate

SUBMITTER: Yan Z 

PROVIDER: S-EPMC9401628 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature