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Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study.

ABSTRACT:

SUBMITTER: Feys S

PROVIDER: S-EPMC9401975 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study.

Feys Simon S Gonçalves Samuel M SM Khan Mona M Choi Sumin S Boeckx Bram B Chatelain Denis D Cunha Cristina C Debaveye Yves Y Hermans Greet G Hertoghs Marjan M Humblet-Baron Stephanie S Jacobs Cato C Lagrou Katrien K Marcelis Lukas L Maizel Julien J Meersseman Philippe P Nyga Rémy R Seldeslachts Laura L Starick Marick Rodrigues MR Thevissen Karin K Vandenbriele Christophe C Vanderbeke Lore L Vande Velde Greetje G Van Regenmortel Niels N Vanstapel Arno A Vanmassenhove Sam S Wilmer Alexander A Van De Veerdonk Frank L FL De Hertogh Gert G Mombaerts Peter P Lambrechts Diether D Carvalho Agostinho A Van Weyenbergh Johan J Wauters Joost J

The Lancet. Respiratory medicine 20220824 12

<h4>Background</h4>Influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated pulmonary aspergillosis (CAPA) affect about 15% of critically ill patients with influenza or COVID-19, respectively. These viral-fungal coinfections are difficult to diagnose and are associated with increased mortality, but data on their pathophysiology are scarce. We aimed to explore the role of lung epithelial and myeloid innate immunity in patients with IAPA or CAPA.<h4>Methods</h4>In this observati ...[more]

PMID: 36029799

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