Developmental stage-specific spontaneous activity contributes to callosal axon projections.

ABSTRACT: The developing neocortex exhibits spontaneous network activity with various synchrony levels, which has been implicated in the formation of cortical circuits. We previously reported that the development of callosal axon projections, one of the major long-range axonal projections in the brain, is activity dependent. However, what sort of activity and when activity is indispensable are not known. Here, using a genetic method to manipulate network activity in a stage-specific manner, we demonstrated that network activity contributes to callosal axon projections in the mouse visual cortex during a 'critical period': restoring neuronal activity during that period resumed the projections, whereas restoration after the period failed. Furthermore, in vivo Ca²⁺ imaging revealed that the

SUBMITTER: Tezuka Y 

PROVIDER: S-EPMC9402231 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature