Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering A_2BAR signaling in intestinal epithelial cells.

ABSTRACT: Intestinal nematode parasites can cross the epithelial barrier, causing tissue damage and release of danger-associated molecular patterns (DAMPs) that may promote host protective type 2 immunity. We investigate whether adenosine binding to the A_2B adenosine receptor (A_2BAR) on intestinal epithelial cells (IECs) plays an important role. Specific blockade of IEC A_2BAR inhibits the host protective memory response to the enteric helminth, Heligmosomoides polygyrus bakeri (Hpb), including disruption of granuloma development at the host-parasite interface. Memory T cell development is blocked during the primary response, and transcriptional analyses reveal profound impairment of IEC activation. Extracellular ATP is visualized 24 h after inoculation and is shown i

SUBMITTER: El-Naccache DW 

PROVIDER: S-EPMC9402265 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature