Transitional Anal Cells Mediate Colonic Re-epithelialization in Colitis.

ABSTRACT:

Background & aims

Epithelial wound healing is compromised and represents an unleveraged therapeutic target in inflammatory bowel disease (IBD). Intestinal epithelial cells exhibit plasticity that facilitates dedifferentiation and repair during the response to injury. However, it is not known whether epithelial cells of a neighboring organ can be activated to mediate re-epithelialization in acute colitis. Histological findings of a permanent squamous tissue structure in the distal colon in human IBD could suggest diverse cellular origins of repair-associated epithelium. Here, we tested whether skin-like cells from the anus mediate colonic re-epithelialization in murine colitis.

Methods

We studied dextran sulfate sodium-induced colitis and interleukin 10-deficient colitis in t

SUBMITTER: Liu CY 

PROVIDER: S-EPMC9402284 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature