Pathogen-Specific Effects of Probiotics in Children With Acute Gastroenteritis Seeking Emergency Care: A Randomized Trial.

ABSTRACT:

Background

It is unknown if probiotics exert pathogen-specific effects in children with diarrhea secondary to acute gastroenteritis.

Methods

Analysis of patient-level data from 2 multicenter randomized, placebo controlled trials conducted in pediatric emergency departments in Canada and the United States. Participants were 3-48 months with >3 diarrheal episodes in the preceding 24 hours and were symptomatic for <72 hours and <7 days in the Canadian and US studies, respectively. Participants received either placebo or a probiotic preparation (Canada-Lactobacillus rhamnosus R0011/Lactobacillus helveticus R0052; US-L. rhamnosus GG). The primary outcome was post-intervention moderate-to-severe disease (ie, ≥9 on the Modified Vesikari Scale [MVS] score).

Results

Pathogens

SUBMITTER: Freedman SB 

PROVIDER: S-EPMC9402642 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature