Three-year Efficacy and Safety of Takeda's Dengue Vaccine Candidate (TAK-003).

ABSTRACT:

Background

Takeda's live attenuated tetravalent dengue vaccine candidate (TAK-003) is under evaluation in a long-term clinical trial across 8 dengue-endemic countries. Previously, we have reported its efficacy and safety in both seronegative and seropositive participants and that its performance varies by serotype, with some decline in efficacy from first to second year postvaccination. This exploratory analysis provides an update with cumulative and third-year data.

Methods

Healthy 4-16 year olds (n = 20099) were randomized 2:1 to receive TAK-003 or placebo (0, 3 month schedule). The protocol included baseline serostatus testing of all participants and detection of all symptomatic dengue throughout the trial with a serotype specific reverse transcriptase-polymerase chain re

SUBMITTER: Rivera L 

PROVIDER: S-EPMC9402653 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature