Sex Differences in Human Immunodeficiency Virus Persistence and Reservoir Size During Aging.

ABSTRACT:

Background

Sex differences in human immunodeficiency virus (HIV) reservoir dynamics remain underexplored.

Methods

Longitudinal samples from virally suppressed midlife women (n = 59, median age 45 years) and age-matched men (n = 31) were analyzed retrospectively. At each time point, we measured sex hormones (by means of enzyme-linked immunosorbent assay) and cellular HIV DNA and RNA (by means of digital droplet polymerase chain reaction). Number of inducible HIV RNA+ cells, which provides an upper estimate of the replication-competent reservoir, was quantified longitudinally in a different subset of 14 women, across well-defined reproductive stages. Mixed-effects models included normalized reservoir outcomes and sex, time since antiretroviral therapy (ART) initiation, and the

SUBMITTER: Gianella S 

PROVIDER: S-EPMC9402699 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature