A combined aging and immune prognostic signature predict prognosis and responsiveness to immunotherapy in melanoma

ABSTRACT: Background: Melanoma is the most lethal, and one of the most aggressive forms of cutaneous malignancies, which poor response to treatment has always puzzled clinicians. As is known to all, aging and immune microenvironment are two crucial factors impacting melanoma biological progress through the tumor microenvironment (TME). However, reliable biomarkers for predicting melanoma prognosis based on aging and immune microenvironment and therapeutic efficacy of immune checkpoints remain to be determined. Methods: The aging-related genes (ARGs) were obtained from the Human Ageing Genomic Resources and immune-related genes (IRGs) were downloaded from the Immunology database as well as Analysis Portal (ImmPort) database. Next, we initially performed LASSO regression and multivariate Cox regressio

SUBMITTER: Lv W 

PROVIDER: S-EPMC9402914 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature