Integrated analysis to reveal potential therapeutic targets and prognostic biomarkers of skin cutaneous melanoma.

ABSTRACT: Skin cutaneous melanoma (SKCM) is a malignant tumor with high mortality rate in human, and its occurrence and development are jointly regulated by genes and the environment. However, the specific pathogenesis of SKCM is not completely understood. In recent years, an increasing number of studies have reported the important role of competing endogenous RNA (ceRNA) regulatory networks in various tumors; however, the complexity and specific biological effects of the ceRNA regulatory network of SKCM remain unclear. In the present study, we obtained a ceRNA regulatory network of long non-coding RNAs, microRNAs, and mRNAs related to the phosphatase and tensin homolog (PTEN) in SKCM and identified the potential diagnostic and prognostic markers related to SKCM. We extracted the above three

SUBMITTER: Zhou X 

PROVIDER: S-EPMC9402985 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature