Identification of m6A- and ferroptosis-related lncRNA signature for predicting immune efficacy in hepatocellular carcinoma.

ABSTRACT:

Background

N6-methyladenosine (m6A) methylation and ferroptosis assist long noncoding RNAs (lncRNAs) in promoting immune escape in hepatocellular carcinoma (HCC). However, the predictive value of m6A- and ferroptosis-related lncRNAs (mfrlncRNAs) in terms of immune efficacy remains unknown.

Method

A total of 365 HCC patients with complete data from The Cancer Genome Atlas (TCGA) database were used as the training cohort, and half of them were randomly selected as the validation cohort. A total of 161 HCC patients from the International Cancer Genome Consortium (ICGC) database were used as external validation (ICGC cohort).

Results

We first identified a group of specific lncRNAs associated with both m6A regulators and ferroptosis-related genes and then constructed progn

SUBMITTER: Xie H 

PROVIDER: S-EPMC9402990 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature