Ontology highlight
ABSTRACT:
SUBMITTER: Postoak JL
PROVIDER: S-EPMC9402993 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Postoak J Luke JL Song Wenqiang W Yang Guan G Guo Xingyi X Xiao Shiyun S Saffold Cherie E CE Zhang Jianhua J Zhang Jianhua J Joyce Sebastian S Manley Nancy R NR Wu Lan L Van Kaer Luc L
The Journal of experimental medicine 20220823 10
The generation of a functional, self-tolerant T cell receptor (TCR) repertoire depends on interactions between developing thymocytes and antigen-presenting thymic epithelial cells (TECs). Cortical TECs (cTECs) rely on unique antigen-processing machinery to generate self-peptides specialized for T cell positive selection. In our current study, we focus on the lipid kinase Vps34, which has been implicated in autophagy and endocytic vesicle trafficking. We show that loss of Vps34 in TECs causes pro ...[more]