Encapsulated vaterite-calcite CaCO₃ particles loaded with Mg²⁺ and Cu²⁺ ions with sustained release promoting osteogenesis and angiogenesis.

ABSTRACT: Bioactive cations, including calcium, copper and magnesium, have shown the potential to become the alternative to protein growth factor-based therapeutics for bone healing. Ion substitutions are less costly, more stable, and more effective at low concentrations. Although they have been shown to be effective in providing bone grafts with more biological functions, the precise control of ion release kinetics is still a challenge. Moreover, the synergistic effect of three or more metal ions on bone regeneration has rarely been studied. In this study, vaterite-calcite CaCO₃ particles were loaded with copper (Cu²⁺) and magnesium (Mg²⁺). The polyelectrolyte multilayer (PEM) was deposited on CaCuMg-CO₃ particles via layer-by-layer technique to fu

SUBMITTER: Fan L 

PROVIDER: S-EPMC9403055 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature