Sex difference in heart failure risk associated with febuxostat and allopurinol in gout patients.

ABSTRACT:

Background

Gout or rapid reduction in serum uric acid level may increase the incidence of heart failure (HF). To compare the risk of HF between febuxostat and allopurinol in gout patients with coexisting cardiovascular (CV) diseases, the varying severity would be likely to confound the risk estimation. Gout and HF are both sex-related diseases, and the risk difference from the urate-lowering agents between women and men remains unknown.

Aims

To evaluate the HF hospitalisations risk of febuxostat and allopurinol in gout patients in real-world settings.

Methods

A population-based cohort enrolled patients with allopurinol or febuxostat initiation from 2011 to 2018. Participants were grouped into, without (low CV risk group) or with (high CV risk group) a history of recen

SUBMITTER: Cheng CL 

PROVIDER: S-EPMC9403180 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature