Ontology highlight
ABSTRACT:
SUBMITTER: Nunziato M
PROVIDER: S-EPMC9403188 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Nunziato Marcella M Di Maggio Federica F Pensabene Matilde M Esposito Maria Valeria MV Starnone Flavio F De Angelis Carmine C Calabrese Alessandra A D'Aiuto Massimiliano M Botti Gerardo G De Placido Sabino S D'Argenio Valeria V Salvatore Francesco F
Frontiers in medicine 20220811
Breast cancer is the most common neoplasia in females worldwide, about 10% being hereditary/familial and due to DNA variants in cancer-predisposing genes, such as the highly penetrant <i>BRCA1/BRCA2</i> genes. However, their variants explain up to 25% of the suspected hereditary/familial cases. The availability of NGS methodologies has prompted research in this field. With the aim to improve the diagnostic sensitivity of molecular testing, a custom designed panel of 44 genes, including also non- ...[more]