Liver biomarkers, genetic and lifestyle risk factors in relation to risk of cardiovascular disease in Chinese.

ABSTRACT:

Background and aims

Liver biomarkers and metabolic associated fatty liver disease (MAFLD) have been shown to be associated with cardiovascular disease (CVD). However, there is limited evidence on CVD subtypes [myocardial infarction (MI), ischemic stroke (IS), and intracerebral hemorrhage (ICH)], especially in the Chinese population. We examined these associations overall, by genetic predisposition to non-alcoholic fatty liver disease (NAFLD), and by lifestyle risk factors.

Approach and results

This is a nested case-control study of CVD (10,298 cases and 5,388 controls) within the China Kadoorie Biobank. Cox regression was used to estimate adjusted hazard ratios (HRs) for CVD associated with liver biomarkers and MAFLD and by stratum of genetic risk and a combined high-risk li

SUBMITTER: Wang X 

PROVIDER: S-EPMC9403237 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature