Teleost Fish and Organoids: Alternative Windows Into the Development of Healthy and Diseased Brains.

ABSTRACT: The variety in the display of animals' cognition, emotions, and behaviors, typical of humans, has its roots within the anterior-most part of the brain: the forebrain, giving rise to the neocortex in mammals. Our understanding of cellular and molecular events instructing the development of this domain and its multiple adaptations within the vertebrate lineage has progressed in the last decade. Expanding and detailing the available knowledge on regionalization, progenitors' behavior and functional sophistication of the forebrain derivatives is also key to generating informative models to improve our characterization of heterogeneous and mechanistically unexplored cortical malformations. Classical and emerging mammalian models are irreplaceable to accurately elucidate mechanisms of stem cells

SUBMITTER: Fasano G 

PROVIDER: S-EPMC9403253 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature