FABP6 Expression Correlates with Immune Infiltration and Immunogenicity in Colorectal Cancer Cells.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) have rapidly revolutionized colorectal cancer (CRC) treatment, but resistance caused by the heterogeneous tumor microenvironment (TME) still presents a challenge. Therefore, it is necessary to characterize TME immune infiltration and explore new targets to improve immunotherapy.

Methods

The compositions of 64 types of infiltrating immune cells and their relationships with CRC patient clinical characteristics were assessed. Differentially expressed genes (DEGs) between "hot" and "cold" tumors were used for functional analysis. A prediction model was constructed to explore the survival of CRC patients treated with and without immunotherapy. Finally, fatty acid-binding protein (FABP6) was selected for in vitro experiments, which re

SUBMITTER: Lian W 

PROVIDER: S-EPMC9403257 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature