An integrative approach to uncover the components, mechanisms, and functions of traditional Chinese medicine prescriptions on male infertility.

ABSTRACT: Male infertility is a major and growing health problem with an estimated global prevalence of 4.2%. The current therapy is limited by the unknown etiology of MI, emphasizing the critical requirement forward to a more efficient method or medication. Through thousands of years, Traditional Chinese Medicine (TCM) has been shown to be effective in treating MI effectively. However, the components, mechanisms and functions of TCM prescriptions on MI are still obscure, severely limiting its clinical application. In order to discover the molecular mechanism of TCM against MI, our study presents a comprehensive approach integrated data mining, network pharmacology, molecular docking, UHPLC-Q-Orbitrap HRMS, and experimental validation. Here, we begin to acquire 289 clinical TCM prescriptions for MI

SUBMITTER: Bai X 

PROVIDER: S-EPMC9403420 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature