Increased expressions of CD123, CD63, CD203c, and Fc epsilon receptor I on blood leukocytes of allergic asthma.

ABSTRACT: Background : Altered basophil identification markers have been discovered to associate with allergic asthma (AA) in recent years. However, little is known about the expression of basophil markers in blood granulocytes. Aim: To parallel test blood basophils in peripheral blood mononuclear cell (PBMC) and granulocyte populations of patients with AA and AA combined with allergic rhinitis (ARA) Methods: The expressions of surface molecules were determined via flow cytometry. CD123 expressing cells in blood were isolated using a cell sorting technique, and mouse AA models were employed for in vivo study. Results: The numbers of CD123⁺HLA-DR^- cells in the granulocytes of AA and ARA patients markedly increased. However, only 4

SUBMITTER: Xie H 

PROVIDER: S-EPMC9403487 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature