Localization of drug biodistribution in a 3D-bioengineered subcutaneous neovascularized microenvironment.

ABSTRACT: Local immunomodulation has shown the potential to control the immune response in a site-specific manner for wound healing, cancer, allergy, and cell transplantation, thus abrogating adverse effects associated with systemic administration of immunotherapeutics. Localized immunomodulation requires confining the biodistribution of immunotherapeutics on-site for maximal immune control and minimal systemic drug exposure. To this end, we developed a 3D-printed subcutaneous implant termed 'NICHE', consisting of a bioengineered vascularized microenvironment enabled by sustained drug delivery on-site. The NICHE was designed as a platform technology for investigating local immunomodulation in the context of cell therapeutics and cancer vaccines. Here we studied the ability of the NICHE to localize t

SUBMITTER: Capuani S 

PROVIDER: S-EPMC9403502 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature