Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study.

ABSTRACT:

Background

This study investigated whether 8-hydroxy-2'-deoxyguanosine (8-OHdG) and N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in the urine could predict bronchopulmonary dysplasia (BPD) in preterm infants.

Methods

This prospective cohort study enrolled 165 preterm infants, of whom 70 developed BPD. We measured urinary 8-OHdG and NT-proBNP concentrations from day of life (DOL) 7 to 28. Then, we evaluated the prediction efficiency by receiver operating characteristic curves and assessed correlations between the two biomarkers. Finally, we identified the predictive risk factors for BPD by multivariable logistic regression.

Results

8-OHdG and NT-proBNP levels were significantly higher from DOL 7 to 28 in the BPD group than in the control group (<

SUBMITTER: Cui X 

PROVIDER: S-EPMC9403535 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature