An enhanced level of VCAM in transplant preservation fluid is an independent predictor of early kidney allograft dysfunction.

ABSTRACT:

Background

We aimed to evaluate whether donor-related inflammatory markers found in kidney transplant preservation fluid can associate with early development of kidney allograft dysfunction.

Methods

Our prospective study enrolled 74 consecutive donated organs who underwent kidney transplantation in our center between September 2020 and June 2021. Kidneys from 27 standard criteria donors were allocated to static cold storage and kidneys from 47 extended criteria donors to hypothermic machine perfusion. ELISA assessment of inflammatory biomarkers (IL-6, IL6-R, ICAM, VCAM, TNFα, IFN-g, CXCL1 and Fractalkine) was analyzed in view of a primary endpoint defined as the occurrence of delayed graft function or slow graft function during the first week following transplantation.

Re

SUBMITTER: Baboudjian M 

PROVIDER: S-EPMC9403542 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature