The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand.

ABSTRACT:

Objective

The mitochondrial nicotinamide adenine dinucleotide (NAD) kinase (MNADK) mediates de novo mitochondrial NADP biosynthesis by catalyzing the phosphorylation of NAD to yield NADP. In this study, we investigated the function and mechanistic basis by which MNADK regulates metabolic homeostasis.

Methods

Generalized gene set analysis by aggregating human patient genomic databases, metabolic studies with genetically engineered animal models, mitochondrial bioenergetic analysis, as well as gain- and loss- of-function studies were performed to address the functions and mechanistic basis by which MNADK regulates energy metabolism and redox state associated with metabolic disease.

Results

Human MNADK common gene variants or decreased expression of the gene are signific

SUBMITTER: Kim H 

PROVIDER: S-EPMC9403569 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature