Associations of cortical iron accumulation with cognition and cerebral atrophy in Alzheimer's disease.

ABSTRACT:

Background

In Alzheimer's disease (AD), cerebral iron accumulation colocalizes with the pathological proteins amyloid-β (Aβ) and tau. Furthermore, tau-induced cortical thinning is associated with cognitive decline. In this study, quantitative susceptibility mapping (QSM) was used to investigate the whole-brain distribution pattern of cortical iron deposition and its relationships with cognition and cortical thickness in AD.

Methods

This cross-sectional study prospectively recruited 30 participants with AD and 26 age- and sex-matched healthy controls (HCs). All participants underwent QSM and T₁-weighted examinations on a 3.0T MRI scanner. Global cognition was assessed using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Whole-bra

SUBMITTER: Yang A 

PROVIDER: S-EPMC9403583 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature