Tumor-Targeted Injectable Double-Network Hydrogel for Prevention of Breast Cancer Recurrence and Wound Infection via Synergistic Photothermal and Brachytherapy.

ABSTRACT: The high locoregional recurrence rate and potential wound infection in breast cancer after surgery pose enormous risks to patient survival. In this study, a polyethylene glycol acrylate (PEGDA)-alginate double-network nanocomposite hydrogel (GPA) embedded with ¹²⁵ I-labeled RGDY peptide-modified gold nanorods (¹²⁵ I-GNR-RGDY) is fabricated. The double-network hydrogel is formed by injection of GPA precursor solutions into the cavity of resected cancerous breasts of mice where gelation occurred rapidly. The enhanced temperature-induced PEGDA polymerization driven by near-infrared light irradiation, and then, the second polymer network is crosslinked between alginate and endogenous Ca²⁺ around the tumor. The double-network hydrogel possesses a dense polymer n

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9403641 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature