A Neuroimaging Signature of Cognitive Aging from Whole-Brain Functional Connectivity.

ABSTRACT: Cognitive decline is amongst one of the most commonly reported complaints during normal aging. Despite evidence that age and cognition are linked with similar neural correlates, no previous studies have directly ascertained how these two constructs overlap in the brain in terms of neuroimaging-based prediction. Based on a long lifespan healthy cohort (CamCAN, aged 19-89 years, n = 567), it is shown that both cognitive function (domains spanning executive function, emotion processing, motor function, and memory) and human age can be reliably predicted from unique patterns of functional connectivity, with models generalizable in two external datasets (n = 533 and n = 453). Results show that cognitive decline and normal aging both manifest decrease within-network connections (especially defau

SUBMITTER: Jiang R 

PROVIDER: S-EPMC9403648 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature