Molecular dynamics simulation insights into the cellular uptake of elastic nanoparticles through human pulmonary surfactant.

ABSTRACT: The interaction between inhaled nanoparticles (NPs) and the pulmonary surfactant (PS) monolayer has drawn significant attention due to its potential in drug delivery design and application for respiratory therapeutics in active and passive cellular uptake pathways. Even though much attention has been given to explore the interaction between NPs and the PS monolayer, the effects of the NP elasticity on the translocation across the PS monolayer have not been thoroughly studied. Here, we performed a series of coarse-grained (CG) molecular dynamics simulations to study active or passive cellular uptake pathways of three NPs with different elasticities through a PS monolayer. The differences between active and passive pathways underly the enhanced targeting ability by ligand-receptor interactio

SUBMITTER: Supakijsilp A 

PROVIDER: S-EPMC9403708 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature