Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patients.

ABSTRACT:

Background

SARS-CoV-2 induces a spectrum of clinical conditions ranging from asymptomatic infection to life threatening severe disease. Host microRNAs have been involved in the cytokine storm driven by SARS-CoV-2 infection and proposed as candidate biomarkers for COVID-19.

Methods

To discover signatures of circulating miRNAs associated with COVID-19, disease severity and mortality, small RNA-sequencing was performed on serum samples collected from 89 COVID-19 patients (34 severe, 29 moderate, 26 mild) at hospital admission and from 45 healthy controls (HC). To search for possible sources of miRNAs, investigation of differentially expressed (DE) miRNAs in relevant human cell types in vitro.

Results

COVID-19 patients showed upregulation of miRNAs associated with

SUBMITTER: Giannella A 

PROVIDER: S-EPMC9403711 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature