Periodontal Stem Cells Synthesize Maresin Conjugate in Tissue Regeneration 3.

ABSTRACT: Periodontal disease is a significant public health problem worldwide. Excess unresolved chronic inflammation destroys the periodontal tissues that surround and support the teeth, and efforts to control inflammation by removal of bacterial deposits on the teeth have limited long-term impact. Likewise, procedures aimed at regeneration of the periodontal tissues have shown limited success. Recent advances in stem cell research have shown promising novel prospects for the use of periodontal ligament stem cells (PDLSCs) in tissue regeneration; however, control of inflammation remains a barrier. Human PDLSCs have been shown to release specialized proresolving lipid mediators (SPMs) that modulate the immune response and promote resolution of inflammation, tissue repair, and regeneration. Studies

SUBMITTER: Rakian A 

PROVIDER: S-EPMC9403725 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature