Saliva microbiome changes in thyroid cancer and thyroid nodules patients.

ABSTRACT:

Objective

Thyroid disease has been reported to associate with gut microbiota, but the effects of thyroid cancer and thyroid nodules on the oral microbiota are still largely unknown. This study aimed to identify the variation in salivary microbiota and their potential association with thyroid cancer and thyroid nodules.

Methods

We used 16S rRNA high-throughput sequencing to examine the salivary microbiota of thyroid cancer patients (n = 14), thyroid nodules patients (n = 9), and healthy controls (n = 15).

Results

The alpha-diversity indices Chao1 and ACE were found to be relatively higher in patients with thyroid cancer and thyroid nodules compared to healthy controls. The beta diversity in both the thyroid cancer and thyroid nodules groups was divergent from the healt

SUBMITTER: Jiao J 

PROVIDER: S-EPMC9403763 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature