Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns.

ABSTRACT:

Importance

Prescription opioids are often used during pregnancy even though they are associated with neonatal opioid withdrawal syndrome (NOWS). Most studies of adverse outcomes of opioid use for pain have assessed only the class-wide outcome despite the pharmacodynamic and pharmacokinetic heterogeneity across opioid medications.

Objective

To compare the risk of NOWS across common types of opioids when prescribed as monotherapy during the last 3 months of pregnancy.

Design, setting, and participants

This cohort study analyzed administrative claims data of Medicaid-insured mothers and newborns in 46 states and Washington DC from January 1, 2000, through December 31, 2014. Participants were mothers with 2 or more dispensed opioid prescriptions within 90 days before deli

SUBMITTER: Esposito DB 

PROVIDER: S-EPMC9403776 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature