The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A ¹H-MRS study in first-episode psychosis patients.

ABSTRACT:

Introduction

Glutamatergic dysfunction is implicated in the pathophysiology of schizophrenia. It is unclear whether glutamatergic dysfunction predicts response to treatment or if antipsychotic treatment influences glutamate levels. We investigated the effect of antipsychotic treatment on glutamatergic levels in the anterior cingulate cortex (ACC), and whether there is a relationship between baseline glutamatergic levels and clinical response after antipsychotic treatment in people with first episode psychosis (FEP).

Materials and methods

The sample comprised 25 FEP patients; 22 completed magnetic resonance spectroscopy scans at both timepoints. Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS).

Results

There was no significant change in glu

SUBMITTER: Zahid U 

PROVIDER: S-EPMC9403834 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature