Functional Connectivity of the Nucleus Accumbens and Changes in Appetite in Patients With Depression.

ABSTRACT:

Importance

Major depressive disorder (MDD) is characterized by a substantial burden on health, including changes in appetite and body weight. Heterogeneity of depressive symptoms has hampered the identification of biomarkers that robustly generalize to most patients, thus calling for symptom-based mapping.

Objective

To define the functional architecture of the reward circuit subserving increases vs decreases in appetite and body weight in patients with MDD by specifying their contributions and influence on disease biomarkers using resting-state functional connectivity (FC).

Design, setting, and participants

In this case-control study, functional magnetic resonance imaging (fMRI) data were taken from the Marburg-Münster FOR 2107 Affective Disorder Cohort Study (MACS),

SUBMITTER: Kroemer NB 

PROVIDER: S-EPMC9403857 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature