[Efficient screening for 8-oxoguanine DNA glycosylase binding aptamers via capillary electrophoresis].
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ABSTRACT:
SUBMITTER: Han S
PROVIDER: S-EPMC9404054 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
[Efficient screening for 8-oxoguanine DNA glycosylase binding aptamers via capillary electrophoresis].
Han Shimiao S Zhao Liping L Yang Ge G Qu Feng F
Se pu = Chinese journal of chromatography 20210701 7
8-Oxoguanine DNA glycosylase (OGG1) is an important enzyme that plays a key role in oxidative DNA damage repair. OGG1 can specifically recognize and excise 8-oxoG (a product of oxidative damage found in double-stranded DNA) through base excision repair (BER). OGG1 is expressed in normal tissues, and in most tumor tissues. Oxidative cellular damage can produce an inflammatory reaction, alleviating some measure of constitutive OGG1 inhibition. OGG1 inhibition in cancer cells shows some promise as ...[more]
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2019-10-18 | GSE136862 | GEO