Novel insight into m6A regulator-mediated methylation modification patterns and immune characteristics in intracranial aneurysm.

ABSTRACT:

Background

Growing evidence demonstrated that m6A modification in cardiovascular diseases. However, how it is involved in the intracranial aneurysm (IA) is still unclear. This study aimed to identify the role of m6A modification in IA.

Methods

Three datasets downloaded from the Gene Expression Omnibus (GEO) database were used, including GSE122897, GSE15629, and GSE3679. The landscapes of 24 m6A regulators were depicted using the STRING database, Pearson's correlation analysis, and Wilcoxon test. The targets of differentially expressed m6A (DEm6A) were predicted in the m6A2Target database and the modification m6A sites of hub targets were identified in SRAMP online tool. A diagnostic model based on DEm6A was constructed and verified in training and test databases. A consensus

SUBMITTER: Li S 

PROVIDER: S-EPMC9404377 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature