Functional roles of ADP-ribosylation writers, readers and erasers.

ABSTRACT: ADP-ribosylation is a reversible post-translational modification (PTM) tightly regulated by the dynamic interplay between its writers, readers and erasers. As an intricate and versatile PTM, ADP-ribosylation plays critical roles in various physiological and pathological processes. In this review, we discuss the major players involved in the ADP-ribosylation cycle, which may facilitate the investigation of the ADP-ribosylation function and contribute to the understanding and treatment of ADP-ribosylation associated disease.

SUBMITTER: Li P 

PROVIDER: S-EPMC9404506 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature